Dexamethasone, effective drug in the critical phases of the coronavirus

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A steroid drug that has been widely available for some time, the anti-inflammatory dexametazone, it could be an effective weapon to save the lives of severe Covid-19 patients. It emerges from a study by the University of Oxford.

The study and effectiveness

The drug would be able to reduce mortality by 35 percent in those patients who needed ventilation. The BBC reported on the largest study in the world that is testing existing treatments. The molecule was administered to 2,000 hospitalized subjects, compared to over 4,000 who did not receive the drug. The risk of death decreased from 40% to 28%, while in patients treated with oxygen it was able to save a life about every 20-25 people. According to Peter Horby, head of the team, this so far the only drug that has been shown to reduce mortality and significantly reduce it. a big step forward. The treatment lasts up to 10 days, the drug costs around 6 eurosOn average, less than € 40 is spent on saving a life, highlights Martin Landray, a researcher at the University of Oxford. Dexamethasone does not seem to help for people with Covid-19 with milder symptoms and who do not need help with breathing. Great Britain will immediately begin administering dexamethasone to coronavirus patients. As we spotted the first signs of dexamethasone’s potential, we have been accumulating it since March, said Health Minister Mart Hancock.

Where is he from

Dexamethasone has been used since the early 1960s to treat a wide range of conditions, such as rheumatoid arthritis and asthma. So far, the only other drug that has been shown to bring benefits to Covid patients with remdesivir, an antiviral treatment that has been used for Ebola. Dexamethasone was used for reduce inflammation and it appears to help stop some of the damage that can occur when the body’s immune system overloads as it tries to fight the coronavirus. The overreaction of the body called cytokine storm and it can be deadly.

Already used in Italy

The efficacy of steroids against some clinical manifestations of Civd-19 is not new: some are being used and experimented and also in Italy the same dexamethasone is used and appears, for example, in the drug guidelines of the Lombardy Region: A benefit of low dose dexamethasone for a limited period of time (10 days) has been recently described in the significant reduction in mortality (…). It seems reasonable to consider the use of dexamethasone only in patients with ARDS (respiratory distress syndrome) confirmed and on an intensivistic indication.

June 16, 2020 (change June 16, 2020 | 4:43 pm)

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