First successes on animals for the vaccine for Coronavirus in China. This was stated in a study published in the journal Cell, according to which the experimentation in China has shown a powerful protective action against Covid-19 of inactivated vaccines that use the killed version of the virus that causes the disease. Research on the BBIBP-CorV vaccine candidate was jointly conducted by the Beijing Institute of Organic Products, part of the China National Biotec Group, the Chinese Center for Disease Control and Prevention, the Chinese Academy of Medical Sciences and other institutions. .
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The researchers report that experimental-scale production of the candidate vaccine induces high levels of neutralizing antibody concentrations in mice, rats, guinea pigs, rabbits and non-human primates, including cynomolgus monkeys and rhesus macaques. A neutralizing antibody can defend a cell from a pathogen or an infectious particle by canceling any biological effect. Two-dose immunizations with two micrograms of each dose provide strong effective protection against intratracheal SARS-CoV-2 in rhesus macaques. No antibody-dependent improvement in the infection was detected in the experiment. Furthermore, according to the research, the vaccine is easy to mass-produce and maintains good genetic stability: an element that supports further evaluation in a clinical study.