Turin, like two thousand oranges a day: the “bomb” of vitamin C that helps fight cancer


It’s time for vitamin C, to which recent studies by the University also attribute a protective anti-coronavirus effect. Certainly its anticancer properties have long been discussed. Now a confirmation, provided that vitamin C is a real “bomb”: a dose equivalent to 2,000 oranges injected intravenously every day for at least two weeks. Thus tumors can be defeated by enhancing the anti-cancer activity of the immune system and making drugs more effective and better tolerated.The study was carried out by the Candiolo Institute and was published in the journal Sciences Translational Medicine. If administered together with checkpoint inhibitors, promising cancer drugs but burdened with various side effects, the overdose of vitamin C enhances immunotherapy and makes it more tolerable, paving the way for new possibilities for integrated therapies that could slow down the disease progression.
The research was carried out on mice with melanomas or tumors in the breast, colon or pancreas, whether or not subjected to oncological immunotherapy. Nothing to do with taking supplements, therefore. To be effective, the study of the Candiolo Institute reveals, vitamin C must be taken in very high doses for a prolonged period.Alberto Bardelli, director of the laboratory of molecular oncology at the Candiolo Institute and full professor of the oncology department of the University recalls that already in the 70s positive data had been recorded on the increase in survival in patients with tumors treated with vitamin C and explains: ” These studies, which have never been adequately substantiated, were abandoned. Recently it was discovered that vitamin C administered orally cannot be absorbed by the intestine at doses that have an anti-cancer effect. So we decided to test mega-doses by injecting them directly “in the peritoneum of mice affected by tumors. The results show that vitamin C alone turns on the T lymphocytes and activates them to respond better to the tumor, which thus significantly slows down its growth.”

Federica Di Nicolantonio, associate professor at the University of Turin and head of the epigenetics laboratory of cancer intervenes by clarifying the relationship of vitamin C with drugs: “We have tried to understand if the effect is maintained even in the case of immunotherapy by co-administering vitamin C together to two checkpoint inhibitor drugs already approved for the teapia of some tumors but burdened with frequent side effects “.

For now, in short, these are important pre-clinical results that will have to be confirmed by subsequent human studies: but the triple therapy with vitamin C and the two checkpoint inhibitors could actually pave the way for new perspectives for treatment.

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