Coronavirus, Lopalco: “Few receptors in children’s noses”

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“Children have little expression of the ACE2 receptor, what SARS-CoV-2 uses to infect cells in the nasal epithelium. The fact that it has few receptors for the virus in what is the gateway to respiratory infections justifies alone the lower susceptibility of children to infection “. Professor Pierluigi Lopalco, epidemiologist at the head of the Apulian task force for the coronavirus emergency, wrote on Facebook, reporting a “Jama communication” that could reveal a “lower contagiousness” of the children. “Good news”, underlines the epidemiologist, on whom “we await further confirmations”.


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“It is clear that children and adolescents get sick more rarely than Covid-19 – says the epidemiologist Lopalco -, but it is still not well known what their role is in spreading the infection. The question is: children are less likely to become infected (and consequently transmit the infection) compared to adults? “. A first finding seems to come from “this Jama communication” according to which “children express little of the ACE2 receptor – what SARS-CoV-2 uses to infect cells in the nasal epithelium”. “If this were the case – concludes Lopalco – the children besides being less sick would become less infected, and would be less contagious”.




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