In fact, the results of an analysis have just been published on Jama a retrospective analysis on RNA from cells of the nasal epithelium of subjects with and without asthma aged between 4 and 60 years inside the Mount Sinai Health System of New York in the period 2015-2018. From the data it emerged that the expression of the ACE2 gene (i.e. the receptor that Sars-Cov2) depends on age: it is lower in children under ten years of age and increases with age. According to the researchers “this could explain the fact that not only children get less sick, but also that they are less contagious“.
And there’s more: according to a recent systematic review of the literature available in Medline and Embase (on 11 May 2020 it examined 700 scientific articles and letters and 47 complete texts) if it is true that the data on the viral load being Covid-19 infections are scarce, however it appears very likely that children have “llower levels than adults and this should reduce, although not cancel the risk of transmission. “Furthermore, studies on transmission in families show that infants are rarely the index case and the case studies suggest that children with Covid-19 rarely cause outbreakthe“.
For other “previous research on the transmission of respiratory diseases suggests that school-age children mainly interact with individuals of the same age, rather than with older people. So the more time children spend in kindergartens and schools, the more they can decrease their exposure to older people, such as grandparents, at risk of serious illness. ”
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